American animated sitcom created by Matt Groening
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- Homer: Why, you little-
- Bart: Eat my shorts!
- Bart: Don't have a cow, man!
- Bart: ¡Ay, caramba!
- Mr. Burns: Release the hounds...
- Dan Castellaneta - Homer Simpson, Abe "Grandpa" Simpson, Krusty the Clown, Barney Gumble, Groundskeeper Willie, Mayor Quimby, Hans Moleman, Sideshow Mel, Squeaky Voiced Teen, Gil Gunderson, Rich Texan, Blue Haired Lawyer, Itchy, Yes Guy, various
- Nancy Cartwright - Bart Simpson (who is of Argentine descent), Nelson Muntz, Ralph Wiggum, Database (a minor character), Kearney (a minor character), various
- Pamela Hayden - Nelson Muntz (Bart the General), Jimbo (who is of Mexican, Cuban and Argentine descent) various
- Julie Kavner - Marge Simpson, Patty Bouvier, Selma Bouvier, Jacqueline Bouvier
- Yeardley Smith - Lisa Simpson
- Hank Azaria - Moe Szyslak, Chief Wiggum, Apu Nahasapeemapetilon, Carl Carlson, Comic Book Guy, Luigi, Lou, Professor Frink, Cletus Spuckler, Superintendent Chalmers, Snake Jailbird, Sea Captain, Kirk Van Houten, Wiseguy, Bumblebee Man, Disco Stu, Dr. Nick, Old Jewish Man, various
- Harry Shearer - Mr. Burns, Waylon Smithers, Ned Flanders, Seymour Skinner, Eddie, Lenny Leonard, Kent Brockman, Reverend Lovejoy, Dr. Hibbert, Scratchy, Otto Mann, Jasper Beardly, Rainer Wolfcastle, various
- Pamela Hayden - Milhouse Van Houten, Jimbo Jones, Rod and Todd Flanders, various
- Tress MacNeille - Agnes Skinner, Crazy Cat Lady, Lindsey Naegle, Manjula, Brandine Spuckler, Dolph, various
- Maggie Roswell - Maude Flanders, Helen Lovejoy, Ms. Hoover, Luann Van Houten, various
- Russi Taylor - Martin Prince, Sherri and Terry, Üter, Lewis, various (died in 2019)
- Grey DeLisle - Martin Prince, Sherri and Terry (replacing Russi Taylor)
Frequent Guest StarsEdit
- Marcia Wallace - Edna Krabappel (character was retired following Wallace's death in 2013)
- Phil Hartman - Lionel Hutz, Troy McClure, various (characters were retired following Hartman's death in 1998)
- Joe Mantegna - Fat Tony
- Frank Welker - Santa's Little Helper, Snowball II, various animals
- Kelsey Grammer - Sideshow Bob
- Jon Lovitz - Artie Ziff, Jay Sherman, Llewelyn Sinclair, various
- Albert Brooks - Various one-time characters
- Glenn Close - Mona Simpson
- Stephen Hawking - Himself (retired following Hawking's death in 2018)
- Doris Grau - Lunchlady Doris (replaced by Tress MacNeille following Grau's death in 1995)
- Jane Kaczmarek - Judge Constance Harm