His early work has included television commercials and minor film and television roles, but his most recognized achievements have come from his highly publicized roles in soap operas. He is best known for playing Dillon Quartermaine on General Hospital (2003–2007), Schuyler Joplin on One Life to Live (2009–2010), and Liam Cooper on The Bold and the Beautiful (2010–present).
In 2007, Clifton became known on YouTube for engaging in philosophical debate and discussion about, among other things, atheism, ethics (with special interest in Biblical ethics), and criticism of Christianity.
- There are three things that they could conceivably do... They could replace me immediately and have somebody else play Dillon. I’m okay with that because I think Dillon needs a reboot. It would be interesting to see somebody else’s take on him. Two, they could kill him, which I would hope they wouldn’t do, just because I would like the opportunity to maybe come back. Depending how they did that, I’d have to go back and shoot that. It would give me a chance to say goodbye and the opportunity to try to pull it together and act well one last time. That would be really profound for me. Or three, they’d have Dillon leave town. I would be wholly and entirely complimented if the door stayed open. I know that’s a lot to ask of them and the door can’t stay open for long. That’s just the rules of the game.
- Responding to the end of his contract with General Hospital and the fate of his role, Dillon Quartermaine, as quoted in "Going Going... Gone" by Rosemary A. Rossi, for ABC Soaps in Depth.
- I’m looking forward to the peace of mind to just write... Songwriting is something that I just fell into. I never expected to love it. But I’ve always had to kind of treat it like a hobby. Now it’s going to feel so good to know that I can just sit down and write.
- Responding to the end of his contract with General Hospital, as quoted in "Going Going... Gone" by Rosemary A. Rossi, for ABC Soaps in Depth.
- In my opinion, if the human race is going to survive, [religion] is something we definitely need to get over — and we're far from over it, and so therefore, I'm far from over it.
- Responding to an interviewer question "if you're such a devout atheist, why are your videos about Christianity? ...Why continuously think about something you've 'allegedly' overcome?" Answers 3 of 5, as Theoretical Bullshit, hosted on YouTube. (06 November 2007)
- Even if the absence of evidence for a given god were not evidence of its absence, it would still be evidence that the belief in that god is unreasonable. That's the only proposition that any atheist of any kind has to demonstrate in order to win the argument. Because anything beyond that... is just having fun.
- In my downtime, for fun, I engage in philosophical internet debates. Yeah, I'm that guy.
- I know that YouTube has made me smarter just by having to think about my views and how to defend them.
- I don’t get to just say what I want, as I work for a company and I have obligations, and so I can’t go around being disrespectful to everybody. However, with as much integrity and respect as possible, I would love any public opportunity to challenge conventional beliefs, especially ones religious in nature and especially ones that have affected my life. Someday it would be great to write a book on that kind of thing. I feel like I have something to say, and it’s not something everyone else is saying.
- Responding to an interviewer's question, "Do you then see yourself being a motivational speaker, or a speaker who gets up and challenges ideology and religion?" in The Scott Clifton Interview – The Bold and the Beautiful, as quoted by Michael Fairman, hosted on Michaelfairmansoaps.com (20 September 2010)
- It's always a source of anxiety, come Emmy time... People are so supportive and so kind, but they put ideas in your head that you don't want to hear. They go, 'I know you're going to win,' and then when you lose, those same people don't want to make eye contact with you. I don't know who's more embarrassed, me or them.