The film was directed by Steve Oedekerk, who was also the principal scriptwriter, and stars the voices of Kevin James, Courteney Cox, Sam Elliot, Danny Glover, Andie MacDowell and Wanda Sykes. Most of the production was carried out in San Clemente, California. It was distributed in Switzerland, Spain and Netherlands by Universal Pictures.
The film is the second Nickelodeon film to be spun-off into a TV series, the first being Jimmy Neutron: Boy Genius.
- Pip: I got a pulse. Wheeee!
- Ben: Otis, a strong man stands up for himself. A stronger man stands up for others.
- Dag: See you around. Get it? "Round"? You're fat.
- Pizza Devilery Guy: Dude, I got a ARM!
- Mrs. Beady: Randall, there is a cow outside.
- Mr. Beady: This is a cow farm. You're going to find cows outside.
- Otis: That's what you call boy tipping!
- Mrs. Beady: Nathan Randall the third, I am not crazy. I am medicated for a chemical imbalance. Don't you sit there and think that I am crazy.
- Ben: Grey market goods. As if I needed to say it again, the purchase of human articles from the gopher underground is strictly prohibited.
- Otis: [Otis cellphone] HELLO MOTO!
[start to play the Motorola tune, Otis coyly answers]
- Gopher: Hey, Otis!
- Gopher: Listen, I think your Nikes are...
- Otis: [whispering] Yeah. This, really isn't the best time...
- Daisy: [feels her stomach] Oh, my... I think, the baby's coming!
- Otis: WHAT?
- Daisy: [giggles] I made you jump.
- Otis: Oh, thank you. Very much. I swallowed my cud!
- Daisy: [laughs, then looks up at the stars] It's so... beautiful...
- Otis: My cud?
- Pig: [watching Daisy giving birth] Man, that looks like it hurts.
- Duke: Oh, that's very profound, "Insight Man".
- Pig: Well, excuse me for being a pig!
- Vision Freddy: Come and get it! [dings the triangle]
- Kevin James as Otis the Cow
- David Koechner as Dag the Coyote
- Jeff Garcia as Pip the Mouse
- Sam Elliott as Ben the Cow
- Courteney Cox as Daisy the Cow
- Tino Insana as Pig
- Dom Irrera as Duke the Dog
- Cam Clarke as Freddy the Ferret
- Danny Glover as Miles the Mule
- Wanda Sykes as Bessie the Cow
- S. Scott Bullock, Maurice LaMarche, and John DiMaggio as The Jersey Cows
- John MiMaggio as Officer O'Hanlon
- Lloyd Sherr as Everett the Dog
- Andie MacDowell as Etta the Hen
- Rob Paulsen as Peck the Rooster
- Madeline Lovejoy as Maddy the Chick
- Nathaniel Stroman as Root the Rooster
- Steve Oedekrek as Eugene Beady
- Steve Oedekrek and Maria Bamford as Mr. and Mrs. Beady
- Jill Talley as Snotty Boy's Mother
- Fred Tatasciore as The Farmer
- Laraine Newman as Snotty Boy's Friend #1
- Katie Leigh as Snotty Boy's Friend #2
- Fred Tatasciore as Farmer Buyer
- Rob Paulsen and Steve Oedekrek as The Pizza Twins
- Rob Paulsen as Wild Mike